This powerful manifesto outlines a vision called theological humanism based on the idea that the integrity of life provides a way to articulate the meaning of religion for the human future. It explores a profound quest to understand the meaning and responsibility of our shared and yet divided humanity amidst the uncertainty of modern society. It articulates the idea that human beings are mixed creatures striving for integrity not only trying to conform to God’s will. It sets forth a dynamic and robust vision of human life beyond the divisions that haunt the humanities, social sciences, theology, and religious studies.