The new covid-19 mutants usually have a higher transmission rate, the maximum positive rate must be lower to ensure that the undetected virus covid-19 carriers are low and the country is controlled. Different countries may face high infection with different covid-19 mutants, Therefore, each country must have a specific maximum positive rate based on its country's covid-19 mutant. This study will create a general formula to determine the maximum positive rate for each country based on its country's covid-19 mutant. 2nd edition has some updates, such as giving some information about Omicron. Therefore, 2nd edition focuses on updating the latest information. Author i) 7 study related covid -19 share as preprint at World Health Organization (WHO), https: //pesquisa.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/?output=site&lang=en&from=0&sort=YEAR_ASC&format=summary&count=20&fb=&page=1&skfp=&index=&q=au%3A%22Chew%2C+Peter%22 ii) Obtain the Certificate of appreciation from Malaysian Health Minister Datuk Seri Dr. Adam Baba(2021), iii)Invited Speaker: Title: Effective Prevention Strategies to Reduce Spread of COVID-19 of the 5th International Conference on Management, Engineering, Science, Social Science and Humanities (iCon-MESSSH'20) https: //youtu.be/uU89i8uO5Qs . iv) Invited Speaker: Title: "End of Covid-19 Pandemic and Prevent Impact on the SustainableDevelopment Goals" of the 6th International Conference on Management, Engineering, Science, Social Science and Humanities . https: //youtu.be/6pPaZDGdpiE v) Invited speaker for LearnT-Spreneurial/ survival/work) Skill, Southeast Asian Ministers of Education Organization, The Regional Centre for Education in Science and Mathematics)(SEAMEO RECSAM ), 2020. ( Online course game base learning to prevent covid 19, https: //youtu.be/z1YHIWrvuwY).