Disability and Inequality:Socioeconomic Imperatives and Public Policy in Jamaica explores the lived experiences of persons with disabilities (PWDs) in Jamaica, examining measurable socioeconomic deficits that establish PWDs are more likely to experience inferior education, training, and labor market outcomes compared to persons without disabilities. The author provides an evidence-based, theoretically grounded, and implementable public policy framework, called Framework of Key Determinants for Political and Socioeconomic Inclusion of PWDs, which advances anti-discrimination legislation and a twin-track policy schema with interconnected enablers of human rights. Using this framework, Jamaica, the Caribbean, and other Southern countries looking for methods and strategies to fulfill commitments set out by the United Nations’ Convention on the Rights of Persons with Disabilities will find approaches to sustain existing progress, and address structural systemic deficits which continue to deny PWDs long-term sustainable development.