The 2nd Vermont Battery mustered into United States service on December 16, 1861, with 111 men, and gained 294 recruits and 51 men transferred from other batteries during its career. Lensie R. Sayles was the battery's first captain, but he resigned within two months. Pythagorus E. Holcomb, of Ohio, assumed command of the battery in Sayles' stead, but was promoted to major in the 1st Texas Cavalry in August 1863. He was replaced by John W. Chase, for whom the battery is named. The battery was engaged at Plain's Store, Louisiana, May 21, 1863, the Siege of Port Hudson, from May 25 to July 9, 1863, and Jackson, August 3, 1863. Original members mustered out on September 20, 1864, and recruits were reorganized as the 1st Company Heavy Artillery, Vermont Volunteers, on March 1, 1865. The battery mustered out of serve on July 31, 1865. The 2nd Vermont Battery suffered 1 died of wounds, 47 died of disease, and 1 died in Confederate prisons, at total of 54 deaths. Other losses included 73 honorably discharged, 6 promoted to other organizations, 121 transferred to the Veteran Reserve Corps or other organizations, and 19 who deserted. The battery suffered 7 men wounded, and 12 taken prisoner.