This workshop was the first of two designed for the purpose of developing specific recommendations for a program of research on adolescent literacy. Together these workshops, jointly sponsored by government and private sector entities, will draw on the knowledge and experiences of researchers and practitioners who work with adolescents and their reading challenges. The March workshop brought together primarily researchers, but also some practitioners, to review and summarize the knowledge base and gaps relevant to adolescent literacy and to develop a research agenda. The format of the workshop was a combination of presentations by speakers, comments from panels of respondents, and open discussion from the audience. This summary report on the workshop contains the following sections: Rationale for the Workshop: Research Needs in Adolescent Literacy; Welcoming Remarks: The Threat and Challenge of Illiteracy; Profiling the Struggling Adolescent Reader: A New Perspective on an Enduring Problem; Adolescent Reading Development: Biological Factors, Predictions; Motivation for Development in Adolescent Literacy; Critical Factors in Instruction–What Should We Be Teaching?; Designs to Study Adolescent Readers; and Designs for High-Quality Interventions. (NEW) I 1.