The radioactive isotope Be-7 was discovered on the forward-facing side of the LDEF satellite in amounts far exceeding that expected from direct cosmic ray activation of the spacecraft material. This prompted an examination of the production of cosmogenic isotopes in the atmosphere and of the processes by which they may be transported to orbital altitudes and absorbed by a spacecraft. Be-7 is only one of several atmospheric cosmogenic isotopes which might be detectable at orbital altitudes and which might prove to be as useful as tracers of atmospheric circulation processes in the mesosphere and thermosphere, as they have been in the lower layers of the atmosphere.