Scholars have studied the nineteenth century’s unprecedented labor flows in global and specific country contexts, but have lacked a comprehensive analysis of the world’s old economic core, the Mediterranean. This work provides answers to important questions, such as: If the Mediterranean labor market really was integrated, then why did globalization affect the Western and Eastern Mediterranean so differently? Why did wage inequality rise in the East while it fell in the rest of the labor-abundant periphery? More broadly, was low emigration from Iberia and the East to blame for the Mediterranean’s failed integration with the fast-expanding global economy? This ground-breaking research relates these questions to ongoing historical debates on the intensity of intra-Mediterranean integration in goods and labor, to current heated debates on North African emigration to Europe, and to discussions on European economic integration more generally.