Intrigued by Aristotle's aphorism "Don't judge a man by the outcome of his decision, judge a man by the intention behind his decision", this book studies human decisions with hidden and malicious intent in business and management, which have led to the collapse of several institutions (from the 1990's to the 2008 Great Recession), and their impact on the market and economy (2008 to present). It identifies an embedded decision space, characterized by (10+8) P's and sub-P's in the Euclidean world in which we live and work, extended to psychological/neurological considerations on decision-makers, quantum field-like on decision entanglement and Minkowski curved decision spacetime-like on decision cause-effect. It draws analogies and homeomorphisms between humans and components of the biological hierarchy. A conceptual AI-augmented human decision investigation process model is proposed based on a cancer analogy (human versus institution), to detect early and correct early human decisions with hidden and malicious intent which affect people, institutions, markets and the economy.