Established as the definitive reference for the IVF clinic, the sixth edition has been extensively revised, with the addition of several important new contributions on clinical topics, including The use of digitalization and precision medicine in the IVF clinic, The environment and reproduction, The use of gonadotropin-releasing hormone agonists and the efficiency of IVF, Controlled ovarian stimulation for freeze-all cycles, Immunology in ART, Home monitoring of ART cycles, Luteal-phase support in ART, The POSEIDON stratification of 'low prognosis' patients in ART, Controlled ovarian stimulation for low responder patients, Adjuvants for poor responders, Innovative therapies in diminished ovarian reserve and primary ovarian insufficiency patients, and Fertility options for transgender and nonbinary individuals. As previously, methods, protocols, and techniques of choice are presented by IVF pioneers and eminent international experts.