John Bitter scanned the hilltops with his field glasses, blaming unfamiliar territory for his uneasy feelings, but past experience taught him not to ignore his hunches. Something's brewing, he thought.

Following Lee's surrender of the Northern Army of Virginia to Grant on April 9, 1865 at Appomattox, Captain John Bitter of Abiqua Creek, Oregon musters out of the 40th Missouri. A loner, Bitter plans a quick ride home over the Oregon Trail. The good Lord, however, has other plans for him. After a month on the Trail, two gun battles, a bruising fistfight to settle a blood feud, a new wife, and two adopted sons, Bitter tells Rockford, his big, mean, black horse, "This sure complicates the business of getting back to Oregon." Bitter now finds himself the leader of a mixed entourage going west: a black pioneer family earlier wagon trains shunned; an Irish rebel turned galvanized Yankee; a dispossessed Cherokee turned Cheyenne medicine man; the rescued sister of a Bannock chief; a white boy adopted by the Cheyenne; and a scout for the Union Army who is also one of the richest men in Oregon. Bitter's Run is a spirited and adventurous tale. Told in three parts, it portrays the realities and uncertainties of life on the Oregon Trail, of war-weary men seeking or returning to a homestead in Oregon, and of the courageous women who rode with them.