Glycan interactions with a variety of glycan binding proteins (GBPs) play a significant role in cell-cell communication, immune evasion, and pathogenic processes. Understanding these interactions is critical to regulating cellular processes and has tremendous therapeutic significance. However, methods to study glycan interactions are relatively limited due to several structural and functional properties of glycans.This work explores specially adapted methods of study, with advances such as glycan microarrays, glycosylated conductive polymers, Luminex bead-based arrays, metabolic labelling, cell surface engineering, and chemo enzymatic labeling. This volume serves as a valuable tool for researchers and industry workers interested in developing and adapting technologies in the detection of glycan-GBP interactions.