This text offers the reader an overview of system-level memory management (data transfer and storage), related issues for complex data-dominated real-time signal and data processing applications. The authors introduce their own system-level data transfer and storage exploration methodology for data-dominated video applications. This methodology tackles the power and area reduction cost components in the architecture for this target domain, namely the system-level busses and the background memories. For the most critical tasks in the methodology, prototype tools have been developed to reduce the design time. The approach is also heavily application-driven which is illustrated by several realistic demonstrators, partly used as red-thread examples in the book. The general applicability and effectiveness has been substantiated for several industrial data-dominated applications, including H263 video conferencing decoding and medical computer tomography (CT) back projection.