Furthering efforts to simulate the potency and specificity exhibited by peptides and proteins in healthy cells, this remarkable reference supplies pharmaceutical scientists with a wealth of techniques for tapping the enormous therapeutic potential of these molecules-providing a solid basis of knowledge for new drug design. Provides a broad, comprehensive overview of peptides and proteins as mediators of cell movement, proliferation, differentiation, and communication. Written by more than 50 leading international authorities, Peptides and Protein Drug Analysis

discusses strategies for dealing with the complexity of peptides and proteins in conformational flexibility and amino acid sequence variability

analyzes drug formulations facilitated by solid-phase peptide synthesis and recombinant DNA technology

examines chemical purity analysis by high-pressure chromatographic, capillary electrophoretic, gel electrophoretic, and isoelectric focusing methods

highlights drug design elements derived from protein folding, bioinformatics, and computational chemistry

demonstrates uses of unnatural mutagenesis and combinatorial chemistry

explores mass spectrometry, protein sequence, and carbohydrate analysis

illustrates bioassays and other new functional analysis methods

surveys spectroscopic techniques such as ultraviolet, fluorescence, Fourier transform infrared, and nuclear magnetic resonance (NMR)

addresses ways of distinguishing between levels of therapeutic and endogenous agents in cells

reviews structural analysis tools such as ultracentrifugation and light, X-ray, and neutron scattering

and more! Featuring over 3400 bibliographic citations and more than 500 tables, equations, and illustrations, Peptide and Protein Drug Analysis is a must-read resource for pharmacists; pharmacologists; analytical, organic, and pharmaceutical chemis