Women’s centers in universities and colleges in the United States are flourishing as they transform individuals and institutions, provide education that combines the academic and activist, and developing leadership that is rooted in collaboration. This handbook provides insights from women’s center directors at institutions across the country on how best to build a women’s center that can improve the quality of women’s experiences in college. The best centers aid universities and colleges in responding to particularly difficult challenges in higher education related to gender. Practical information is included on specific programs, providing an overview of successful centers. The institutional environments examined are diverse, ranging from research universities to community colleges, from large state-supported land grant institutions to small private liberal arts colleges.