Evolution of Translational Omics: Lessons Learned and the Path Forward

Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials,Board on Health Care Services,Institute of Medicine,Board on Health Sciences Policy

Evolution of Translational Omics: Lessons Learned and the Path Forward
Format
Paperback
Publisher
National Academies Press
Country
United States
Published
15 December 2012
Pages
300
ISBN
9780309224185

Evolution of Translational Omics: Lessons Learned and the Path Forward

Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials,Board on Health Care Services,Institute of Medicine,Board on Health Sciences Policy

Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient’s likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.

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