The Unified Protocols for Transdiagnostic Treatment of Emotional Disorders in Children (UP-C) and Adolescents (UP-A) are evidence-based interventions originally designed to target core dysfunctions underlying emotional disorders, such as anxiety and depressive disorders, in children and adolescents. However, the UP-C and UP-A re increasingly being used to address other diagnostic clusters and problem areas that share these same core dysfunctions in a diverse range of delivery settings and cultural contexts. Applications of the Unified Protocols for Transdiagnostic Treatment of Emotional Disorders in Children and Adolescents is a practical guide for clinicians and researchers on applying the core principles of the UP-C and UP-A to treat children and adolescents with a broad range of emotion disturbance across settings in which youth typically receive care, including community mental health settings, pediatric primary care, and telehealth. In addition to providing an overview of the rationale for using UP-C and/or UP-A with each presenting problem or within each delivery setting, chapters provide detailed, step-by-step guidance on adapting and applying the UP-C and UP-A for their particular problem area, delivery setting, or cultural context. Chapters include case examples, suggestions for overcoming potential barriers in clinical delivery, and practical tip sheets for clinicians. When used in conjunction with the UP-C and UP-A Therapist Guide and Workbooks, this volume is an essential resource for clinicians using transdiagnostic interventions to treat diverse, complex, and comorbid clients in real-world therapy settings.