When Charles Miller Fisher was born in 1913 there was very little scientific knowledge about stroke. But thanks to him, our understanding of stroke and of other brain disorders are now well established in every neurology training program around the world. C. Miller Fisher is his story: his life, his method of study and of research, and his contributions. This work, reinforced with unequalled access to the CMF archives overseen by the Fisher estate and told in his own words (italicized in the text) from his memoirs, will shed light on one of the most important clinicians in North America and the world. He devoted his career and the great majority of every waking day to the study of stroke, both in the pathology laboratory and in people. Fisher’s discoveries and contributions and those of the individuals that he trained changed the knowledge basis of stroke and vascular disease for everyone.