Urban renewal has been the dominant approach to revitalizing industrialized communities that fall into decline. A national, community-based organization, the Skillman Foundation sought to engage in a joint effort with the University of Michigan’s School of Social Work to bring six neighborhoods in one such declining urban center, Detroit, back to positions of strength and national leadership. A Twenty-First Century Approach to Community Change introduces readers to the basis for the Foundation’s solicitation of social work expertise and the social context within which the work of technical assistance began. Building on research, the authors introduce the theory and practice knowledge of earlier scholars, including the conduct of needs assessments at multiple levels, engagement of community members in identifying problem-solving strategies, assistance in developing community goals, and implementation of social work field instruction opportunities. Lessons learned and challenges are described as they played out in the process of creating partnerships for the Foundation with community leaders, engaging and maintaining youth involvement, managing roles and relationships with multiple partners recruited by the Foundation for their specialized expertise, and ultimately conducting the work of technical assistance within a context of increasing influence of the city’s surrounding systems (political, economic, educational, and social). Readers will especially note the role of technical assistance in an evolving theory of change.