Weaving together research findings and narratives, Culture of Health in Practice: Innovations in Research, Community Engagement, and Action explores the many opportunities we have as a society to advance a Culture of Health and makes the case that a commitment to health equity is fundamental to bringing those efforts into the mainstream. In this latest contribution to the Robert Wood Johnson Foundation’s Culture of Health Series, contributors describe the challenges and opportunities in rural and urban regions, in neighborhoods and schools, in prisons and workplaces. They explore different populations, including immigrants, minority youth, and individuals with substance use disorders; the risks posed by climate change; the role of the media in shaping the public discourse; and the innovations being spearheaded by health providers, insurers, and community leaders. Together, the chapters carry the message that while the challenges are daunting, achieving health equity for all lies within reach.