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      Cover image for Genome-Based Diagnostics: Clarifying Pathways to Clinical Use: Workshop Summary
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      Genome-Based Diagnostics: Clarifying Pathways to Clinical Use: Workshop Summary

      Roundtable on Translating Genomic-Based Research for Health,Board on Health Sciences Policy,Institute of Medicine

      The sequencing of the human genome and the identification of associations between specific genetic variants and diseases have led to an explosion of genomic-based diagnostic tests. These tests have the…

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      Cover image for Genome-Based Therapeutics: Targeted Drug Discovery and Development: Workshop Summary
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      Genome-Based Therapeutics: Targeted Drug Discovery and Development: Workshop Summary

      Institute of Medicine,Board on Health Sciences Policy,Roundtable on Translating Genomic-Based Research for Health

      The number of new drug approvals has remained reasonably steady for the past 50 years at around 20 to 30 per year, while at the same time the total spending…

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      Cover image for Engaging the Public in Critical Disaster Planning and Decision Making: Workshop Summary
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      Engaging the Public in Critical Disaster Planning and Decision Making: Workshop Summary

      Institute of Medicine,Board on Health Sciences Policy,Forum on Medical and Public Health Preparedness for Catastrophic Events

      Constitutes the summary of a workshop held in March 2013 to discuss the key principles of public engagement during the development of disaster plans, the response phase, and during the…

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      Cover image for Preparedness, Response, and Recovery Considerations for Children and Families: Workshop Summary
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      Preparedness, Response, and Recovery Considerations for Children and Families: Workshop Summary

      Forum on Medical and Public Health Preparedness for Catastrophic Events,Board on Health Sciences Policy,Institute of Medicine

      Presents the summary of a workshop convened in June, 2013 by the Institute of Medicine Forum on Medical and Public Health Preparedness for Catastrophic Events to discuss disaster preparedness, response…

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      Cover image for Certifying Personal Protective Technologies: Improving Worker Safety
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      Certifying Personal Protective Technologies: Improving Worker Safety

      Committee on the Certification of Personal Protective Technologies,Institute of Medicine

      When you purchase a product, you expect it to work. Construction workers on high-rise buildings need to be confident that their safety harnesses will arrest a fall. Firefighters need to…

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      Cover image for Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness
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      Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness

      Institute of Medicine,Board on the Health of Select Populations,Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

      Myalgic encephalomyelitis (ME) and chronic fatigue syndrome (CFS) are serious, debilitating conditions that affect millions of people in the United States and around the world. ME/CFS can cause significant impairment…

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      Cover image for Discussion Framework for Clinical Trial Data Sharing: Guiding Principles, Elements, and Activities
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      Discussion Framework for Clinical Trial Data Sharing: Guiding Principles, Elements, and Activities

      Institute of Medicine,Board on Health Sciences Policy,Committee on Strategies for Responsible Sharing of Clinical Trial Data

      Discussion Framework for Clinical Trial Data Sharing: Guiding Principles, Elements, and Activities is part of a study of how data from clinical trials might best be shared. This document is…

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      Cover image for Venture Philanthropy Strategies to Support Translational Research
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      Venture Philanthropy Strategies to Support Translational Research

      Forum on Neuroscience and Nervous System Disorders,Institute of Medicine

      Many voluntary health organizations fund translational research. An increasing number of these organizations are looking at venture philanthropy as a critical way to advance their missions of helping patients and…

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      Cover image for Neurodegeneration: Exploring Commonalities Across Diseases: Workshop Summary
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      Neurodegeneration: Exploring Commonalities Across Diseases: Workshop Summary

      Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

      Presents the summary of a workshop hosted by the Institute of Medicine\‘s (IOM\’s) Forum on Neuroscience and Nervous System Disorders in Spring 2012 to explore commonalities across neurodegenerative diseases such…

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      Cover image for Amyotrophic Lateral Sclerosis in Veterans: Review of the Scientific Literature
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      Amyotrophic Lateral Sclerosis in Veterans: Review of the Scientific Literature

      Institute of Medicine,Board on Population Health and Public Health Practice,Committee on the Review of the Scientific Literature on Amyotrophic Lateral Sclerosis in Veterans,National Academy of Sciences

      Amyotrophic lateral sclerosis (ALS) our Lou Gehrig’s disease is a fatal, mostly non-familial disease that affects the nervous system of humans by causing the degeneration of nerve cells in the…

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      Cover image for HIV Screening and Access to Care: Health Care System Capacity for Increased HIV Testing and Provision of Care
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      HIV Screening and Access to Care: Health Care System Capacity for Increased HIV Testing and Provision of Care

      Committee on HIV Screening and Access to Care,Institute of Medicine

      Increased HIV screening may help identify more people with the disease, but there may not be enough resources to provide them with the care they need. The Institute of Medicine’s…

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      Cover image for Epilepsy Across the Spectrum: Promoting Health and Understanding
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      Epilepsy Across the Spectrum: Promoting Health and Understanding

      Institute of Medicine,Board on Health Sciences Policy,Committee on the Public Health Dimensions of the Epilepsies

      Although epilepsy is one of the nation’s most common neurological disorders, public understanding of it is limited. Many people do not know the causes of epilepsy or what they should…

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      Cover image for BioWatch and Public Health Surveillance: Evaluating Systems for the Early Detection of Biological Threats: Abbreviated Version
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      BioWatch and Public Health Surveillance: Evaluating Systems for the Early Detection of Biological Threats: Abbreviated Version

      Committee on Effectiveness of National Biosurveillance Systems: BioWatch and the Public Health System,National Research Council

      Following the attacks of September 11, 2001 and the anthrax letters, the ability to detect biological threats as quickly as possible became a top priority. In 2003 the Department of…

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      Cover image for Future of Emergency Care: Dissemination Workshop Summaries
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      Future of Emergency Care: Dissemination Workshop Summaries

      In June 2006, the Institute of Medicine (IOM) Committee on the Future of Emergency Care in the U.S. Health System released a series of reports on the state of emergency…

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      Cover image for Fitness Measures and Health Outcomes in Youth
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      Fitness Measures and Health Outcomes in Youth

      Committee on Fitness Measures and Health Outcomes in Youth,Food and Nutrition Board,Institute of Medicine

      Physical fitness affects our ability to function and be active. At poor levels, it is associated with such health outcomes as diabetes and cardiovascular disease. Physical fitness testing in American…

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      Cover image for Gulf War and Health: Volume 5: Infectious Diseases
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      Gulf War and Health: Volume 5: Infectious Diseases

      Institute of Medicine,Board on Population Health and Public Health Practice,Committee on Gulf War and Health: Infectious Diseases

      Provides an assessment of the scientific literature on potential health effects of exposure to certain biological, chemical, and environmental agents associated with the Gulf War.

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      Cover image for HIV Screening and Access to Care: Exploring the Impact of Policies on Access to and Provision of HIV Care
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      HIV Screening and Access to Care: Exploring the Impact of Policies on Access to and Provision of HIV Care

      Committee on HIV Screening and Access to Care,Institute of Medicine

      With the widespread use of highly active anti-retroviral treatment (HAART), HIV has become a chronic, rather than a fatal, disease. But for their treatment to succeed, patients require uninterrupted care…

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      Cover image for Leveraging Culture to Address Health Inequalities: Examples from Native Communities: Workshop Summary
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      Leveraging Culture to Address Health Inequalities: Examples from Native Communities: Workshop Summary

      Institute of Medicine,Board on Population Health and Public Health Practice,Roundtable on the Promotion of Health Equity and the Elimination of Health Disparities

      Presents the summary of a workshop convened in November 2012 by the Roundtable on the Promotion of Health Equity and the Elimination of Health Disparities of the Institute of Medicine.

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      Cover image for The Utility of Proximity-Based Herbicide Exposure Assessment in Epidemiologic Studies of Vietnam Veterans
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      The Utility of Proximity-Based Herbicide Exposure Assessment in Epidemiologic Studies of Vietnam Veterans

      Committee on Making Best Use of the Agent Orange Exposure Reconstruction Model

      A fundamental challenge in past studies evaluating whether health problems experienced by Vietnam veterans might be linked to wartime use of Agent Orange or other herbicides has been a lack…

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      Cover image for Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute
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      Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute

      National Research Council,Institute of Medicine,Nuclear and Radiation Studies Board,Board on the Health of Select Populations,Committee on Research Directions in Human Biological Effects of Low-Level Ionizing Radiation

      Support for this project was provided by the National Academy of Sciences and the Uniformed Sciences University of the Health Sciences under Grant No. HT9404-12-1-0028. –Title page verso.

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      Cover image for Implementing a National Cancer Clinical Trials System for the 21st Century: Second Workshop Summary
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      Implementing a National Cancer Clinical Trials System for the 21st Century: Second Workshop Summary

      Board on Health Care Services,National Cancer Policy Forum,Institute of Medicine

      In early 2011, the NCPF and the American Society of Clinical Oncology (ASCO) held a workshop in which stakeholders discussed the changes they planned to implement in response to the…

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      Cover image for Dispensing Medical Countermeasures for Public Health Emergencies: Workshop Summary
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      Dispensing Medical Countermeasures for Public Health Emergencies: Workshop Summary

      Forum on Medical and Public Health Preparedness for Catastrophic Events,Institute of Medicine

      On March 3-4, 2008, the Institute of Medicine (IOM) Forum on Medical and Public Health Preparedness for Catastrophic Events hosted a workshop titled ‘Medical Countermeasures Dispensing’. This book highlights the…

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      Cover image for Exploring the Biological Contributions to Human Health: Does Sex Matter
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      Exploring the Biological Contributions to Human Health: Does Sex Matter

      Committee on Understanding the Biology of Sex and Gender Differences,Board on Health Sciences Policy,Institute of Medicine

      Discusses basic biochemical differences in the cells of males and females and health variability between the sexes from conception throughout life. This book identifies key research needs and opportunities and…

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      Cover image for Review of NASA's Evidence Reports on Human Health Risks: 2015 Letter Report
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      Review of NASA’s Evidence Reports on Human Health Risks: 2015 Letter Report

      National Academies of Sciences, Engineering, and Medicine,Institute of Medicine,Board on Health Sciences Policy,Committee to Review NASA's Evidence Reports on Human Health Risks

      Review of NASA’s Evidence Reports on Human Health Risks 2015 Letter Report is the third in a series of five reports from the Institute of Medicine that will independently review…

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      Cover image for Measuring Serious Emotional Disturbance in Children: Workshop Summary
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      Measuring Serious Emotional Disturbance in Children: Workshop Summary

      National Academies of Sciences, Engineering, and Medicine,Institute of Medicine,Board on Health Sciences Policy,Division of Behavioral and Social Sciences and Education,Board on Behavioral, Cognitive, and Sensory Sciences

      The workshop summarized in this report was organized as part of a study sponsored by the Substance Abuse and Mental Health Services Administration (SAMHSA) and the Office of the Assistant…

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      Cover image for Financing Vaccines in the 21st Century: Assuring Access and Availability
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      Financing Vaccines in the 21st Century: Assuring Access and Availability

      Committee on the Evaluation of Vaccine Purchase Financing in the United States,National Academy of Sciences

      The national immunization system has achieved high levels of immunization, particularly for children. However, this system faces challenges. This book addresses these challenges by proposing strategies for assuring access to…

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      Cover image for Rewarding Provider Performance: Aligning Incentives in Medicare
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      Rewarding Provider Performance: Aligning Incentives in Medicare

      Committee on Redesigning Health Insurance Performance Measures, Payment, and Performance Improvement Programs,National Academy of Sciences

      Addresses the topic of quality of health care in America. This book evaluates specific policy approaches within the context of improving operational framework of health care system. It offers options…

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      Cover image for The 2009 H1N1 Influenza Vaccination Campaign: Summary of a Workshop Series
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      The 2009 H1N1 Influenza Vaccination Campaign: Summary of a Workshop Series

      Forum on Medical and Public Health Preparedness for Catastrophic Events,Institute of Medicine

      In the year 2008, I lost someone very dear to my heart, and at that same time I watched my earnings dwindle to one-fourth. I almost lost all hope in…

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      Cover image for Priority Areas for National Action: Transforming Health Care Quality
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      Priority Areas for National Action: Transforming Health Care Quality

      Committee on Identifying Priority Areas for Quality Improvement,Board on Health Care Services,Institute of Medicine,National Academy of Sciences

      A new release in the Quality Chasm Series, Priority Areas for National Action recommends a set of 20 priority areas that the U.S. Department of Health and Human Services and…

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      Cover image for Crisis Standards of Care
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      Crisis Standards of Care

      Forum on Medical and Public Health Preparedness for Catastrophic Events,Institute of Medicine

      During a wide-reaching catastrophic public health emergency or disaster, existing surge capacity plans may not be sufficient to enable healthcare providers to continue to adhere to normal treatment procedures and…

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      Cover image for Cognitive Aging: Progress in Understanding and Opportunities for Action
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      Cognitive Aging: Progress in Understanding and Opportunities for Action

      Institute of Medicine,Board on Health Sciences Policy,Committee on the Public Health Dimensions of Cognitive Aging

      For most Americans, staying mentally sharp as they age is a very high priority. Declines in memory and decision-making abilities may trigger fears of Alzheimer’s disease or other neurodegenerative diseases…

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      Cover image for Medical Devices and the Public's Health: The FDA 510(k) Clearance Process at 35 Years
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      Medical Devices and the Public’s Health: The FDA 510(k) Clearance Process at 35 Years

      Committee on the Public Health Effectiveness of the FDA 510(k) Clearance Process,Institute of Medicine

      Medical devices that are deemed to have a moderate risk to patients generally cannot go on the market until they are cleared through the FDA 510(k) process. In recent years…

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      Cover image for Ovarian Cancers: Evolving Paradigms in Research and Care
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      Ovarian Cancers: Evolving Paradigms in Research and Care

      National Academies of Sciences, Engineering, and Medicine,Institute of Medicine,Board on Health Care Services,Committee on the State of the Science in Ovarian Cancer Research

      In an era of promising advances in cancer research, there are considerable and even alarming gaps in the fundamental knowledge and understanding of ovarian cancer. Researchers now know that ovarian…

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      Cover image for Identifying and Addressing the Needs of Adolescents and Young Adults with Cancer: Workshop Summary
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      Identifying and Addressing the Needs of Adolescents and Young Adults with Cancer: Workshop Summary

      Institute of Medicine,Board on Health Care Services,National Cancer Policy Forum

      Presents the summary of a workshop convened by the Institute of Medicine’s National Cancer Policy Forum in July 2013 to facilitate discussion about gaps and challenges in caring for adolescent…

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      Cover image for Veterans and Agent Orange: Update 2012
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      Veterans and Agent Orange: Update 2012

      Institute of Medicine,Board on the Health of Select Populations,Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Ninth Biennial Update)

      Reviews peer-reviewed scientific reports concerning associations between health outcomes and exposure to TCDD and other chemicals in the herbicides used in Vietnam that were published in October 2010 - September…

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      Cover image for The New Profile of Drug-Resistant Tuberculosis in Russia: A Global and Local Perspective: Summary of a Joint Workshop
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      The New Profile of Drug-Resistant Tuberculosis in Russia: A Global and Local Perspective: Summary of a Joint Workshop

      Forum on Drug Discovery, Development, and Translation,Institute of Medicine,Russian Academy of Medical Sciences

      An estimated 2 billion people, one third of the global population, are infected with Mycobacterium tuberculosis, the bacterium that causes tuberculosis. Spread through the air, this infectious disease killed 1.7…

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      Cover image for A Population-Based Policy and Systems Change Approach to Prevent and Control Hypertension
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      A Population-Based Policy and Systems Change Approach to Prevent and Control Hypertension

      Committee on Public Health Priorities to Reduce and Control Hypertension,Institute of Medicine

      Hypertension is one of the leading causes of death in the United States, affecting nearly one in three Americans. It is prevalent in adults and endemic in the older adult…

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      Cover image for Keeping Patients Safe: Transforming the Work Environment of Nurses
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      Keeping Patients Safe: Transforming the Work Environment of Nurses

      Institute of Medicine,Board on Health Care Services,Committee on the Work Environment for Nurses and Patient Safety

      Building on the Institute of Medicine reports, this work lays out guidelines for improving patient safety by changing nurses working conditions and demands. It discusses the key aspects of the…

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      Cover image for The Childhood Immunization Schedule and Safety: Stakeholder Concerns, Scientific Evidence, and Future Studies
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      The Childhood Immunization Schedule and Safety: Stakeholder Concerns, Scientific Evidence, and Future Studies

      Committee on the Assessment of Studies of Health Outcomes Related to the Recommended Childhood Immunization Schedule,Board on Population Health and Public Health Practice,Institute of Medicine

      Reviews scientific findings and stakeholders concerns related to the safety of the recommended childhood immunization schedule. This report identifies potential research approaches, methodologies and study designs that could inform this…

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      Cover image for Preserving Public Trust: Accreditation and Human Research Participant Protection Programs
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      Preserving Public Trust: Accreditation and Human Research Participant Protection Programs

      Institute of Medicine,Board on Health Sciences Policy,Committee on Assessing the System for Protecting Human Research Subjects

      Considers the impact of creating an accreditation system to raise the performance of local protection mechanisms. This report examines two draft sets of accreditation standards for their content in core…

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      Cover image for Preventing Medication Errors
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      Preventing Medication Errors

      Committee on Identifying and Preventing Medication Errors

      Part of the Quality Chasm Series , this book sets forth an agenda for improving the safety of medication use. It provides an overview of the system for drug development…

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      Cover image for Prepositioning Antibiotics for Anthrax
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      Prepositioning Antibiotics for Anthrax

      Committee on Prepositioned Medical Countermeasures for the Public,Institute of Medicine

      If terrorists released Bacillus anthracis over a large city, hundreds of thousands of people could be at risk of the deadly disease anthrax-caused by the B. anthracis spores-unless they had…

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      Cover image for Assessing Readiness in Military Women: The Relationship of Body, Composition, Nutrition, and Health
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      Assessing Readiness in Military Women: The Relationship of Body, Composition, Nutrition, and Health

      Committee on Body Composition, Nutrition, and Health of Military Women,Institute of Medicine,National Academy of Sciences

      In 1992, the Committee on Military Nutrition Research reviewed the existing standards and found that the standards for body composition required for women to achieve an appearance goal seemed to…

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      Cover image for Supporting a Movement for Health and Health Equity: Lessons from Social Movements: Workshop Summary
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      Supporting a Movement for Health and Health Equity: Lessons from Social Movements: Workshop Summary

      Institute of Medicine,Board on Population Health and Public Health Practice,Roundtable on the Promotion of Health Equity and the Elimination of Health Disparities,Roundtable on Population Health Improvement

      Supporting a Movement for Health and Health Equity is the summary of a workshop convened in December 2013 by the Institute of Medicine Roundtable on the Promotion of Health Equity…

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      Cover image for The Personal Protective Technology Program at NIOSH
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      The Personal Protective Technology Program at NIOSH

      Reviews of Research Programs of the National Institute for Occupational Safety and Health,Committee to Review the NIOSH Personal Protective Technology Program,Institute of Medicine,National Research Council

      Examines the National Institute for Occupational Safety and Health personal protective technology program. This book focuses on the relevance and impact of this program in reducing hazardous exposures and in…

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      Cover image for Amendments to the National Academies' Guidelines for Human Embryonic Stem Cell Research
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      Amendments to the National Academies’ Guidelines for Human Embryonic Stem Cell Research

      Human Embryonic Stem Cell Research Advisory Committee,National Research Council,Institute of Medicine,National Academies

      In 2005, the National Academies released the report Guidelines for Human Embryonic Stem Cell Research . In order to keep the guidelines up to date, the Human Embryonic Stem Cell…

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      Cover image for Emerging Safety Science: Workshop Summary
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      Emerging Safety Science: Workshop Summary

      Sally Robinson,Robert Pool,Robert Giffin,Forum on Drug Discovery, Development, and Translation,Institute of Medicine

      The average cost of developing a new approved drug is now estimated to be $1.3 billion. This title offers ways to select successful drug candidates earlier in development that could…

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      Cover image for Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease
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      Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease

      Committee on Qualifications of Biomarkers and Surrogate Endpoints in Chronic Disease,Institute of Medicine

      Many people naturally assume that the claims made for foods and nutritional supplements have the same degree of scientific grounding as those for medication, but that is not always the…

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