This book presents a state-of-the-art study of 3D-printing technologies for medical applications, with particular focus on the development of a computer-aided scaffold design system; the direct 3D printing of functionally graded scaffolds; the modelling of selective laser sintering (SLS) and fused deposition modelling (FDM) processes; the indirect additive manufacturing of scaffolds, with both micro and macro features. Technological limitations will be discussed so as to highlight the possibility of future improvements for new 3D-printing methodologies for Bone scaffold.