Signal Transduction and the Coordination of B Lymphocyte Development and Function I: Transduction of BCR Signals from the Cell Membrane to the Nucleus

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This volume provides a review of current research in the field of B cell development and differentiation with particular emphasis on signal transduction processes. The volume is divided into two parts that focus, respectively, on the basic biochemical pathways which regulate B cell biology and the role of signal transduction processes in regulating various aspects of B cell function, development and differentiation. The chapters incorporated in part I include discussions of receptor mediated biochemical events that occur at the membrane, the intermediate pathways that transduce activation signals through the cell and, finally, the molecular events which regulate gene transcription in the nucleus of the B cell. In summary, the volume as a whole is designed to provide readers with an overview of signal transduction in the B cell and the role which signaling processes play in regulation of specific physiological events.