Geneticists Clive Nicoli and Elsa Kast are on the verge of a revolutionary breakthrough when they are forced underground by a closed-minded world, fearful of tampering in God's domain. There in the shadows they create Dren, a hybrid born of beast and man whose potential exceeds their wildest dreams...but Dren becomes their worst nightmare when she grows too strong to contain, too smart to control, and too seductive to resist.

From the subversive imagination of Vincenzo Natali, SPLICE is a story about human nature: the universal qualities that bind us, and the aberrations that set us apart. This Frankensteinian fable of freak science and found family explores the pain of difference, while revealing our surprising kinship with the uncanny.