After a number of earthquakes hammer the Sierra Madre region of Mexico, Grupo Verdugo, a splinter group of cartel enforcers, takes control of the drug shipping routes through that territory. Caught in the middle, a small orphanage high in the mountains, desperate for supplies to care for the children and the battered earthquake victims, reaches out to Abel Yeager for help. Yeager and his friend Victor agree to deliver the needed food and medicine. But Grupo Verdugo seems to have a special interest in starving out the clergy and forcing them to bend to their will. They send a man known as the Executioner to stop anyone daring to assist the people.

Yeager and Victor are in for the biggest fight of their lives as they are forced to move forty children, a dozen sick and injured patients, and one feisty doctor out of the mission and through mountains infested with vicious killers.