This critical edition and annotated translation of metrical homilies attributed to Isaac of Antioch includes twenty texts, the majority of which are examples of the Syriac rebuke genre. The introduction provides the first detailed study of the manuscript tradition of the entire corpus, identifies four different Isaacs whose writings were intermingled in late antiquity, and develops criteria for distinguishing among their works. Scholars and students of church history will find this a valuable resource for the study of late fifth-century CE Syriac poetry and homiletics, Christian ideas of moral reform, and late antique monastic and lay devotional culture.