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Metastasis to bone is a common event in cancer. However, due to the skeleton’s unique structure, exploring how cancer cells target the skeleton and interact with the bone microenvironment is challenging. The Biology of Skeletal Metastases covers areas that are important to both clinicians and basic scientists seeking an enhanced understanding of mechanisms of skeletal metastasis, as well as descriptions of cutting edge therapies for skeletal metastases. Both increased efforts by many investigators and advances in research methodologies have provided a wealth of information in the area of skeletal metastases. The Biology of Skeletal Metastases brings together experts to describe these many advances. This book provides background in basic bone biology and biology of metastasis for novice investigators and highlights many advances in this challenging field for the experienced investigator. The Biology of Skeletal Metastases includes chapters on the following: - basic biology of the metastatic process and the specific biology of skeletal metastasis including tumor targeting to bone; - interactions between the tumor and bone microenvironment and the development of tumor-induced osteoclastic and osteoblastic lesions; - specific effectors of bone metastasis including macrophage inflammatory protein, collagen-I, parathyroid hormone-related protein, receptor activator of nuclear factor kappa B, endothelins, and matrix metalloproteinases. Research methodologies such as animal models of skeletal metastasis are reviewed.Furthermore, developments in clinical aspects of skeletal metastasis including bisphosphonate and gene therapies are addressed in this comprehensive book (including 12 pages of full color illustrations). ‘Skeletal metastases are both a common and devastating consequence of a spectrum of cancers. Significant advances have occurred in our understanding of the pathobiology of this process. This text provides a comprehensive review of current investigative findings and their clinical implications.’ Steven T. Rosen, M.D. Series Editor
