Cell Culture Methods for In Vitro Toxicology

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This text introduces the reader to a range of techniques involved in the use of in vitro cell culture in toxicological studies. It deals with all the major cell types studied in the field of toxicology and should be useful for anyone wishing to start work with animal cell cultures or to refresh their knowledge relating to in vitro cell models. Fundamental chapters deal with the general biology of cytotoxicity and these are key issues for in vitro systems addressing the 3Rs principle. Up-to-date overviews deal with the use of cells from liver, brain, skin, and intestine. In addition, biochemical analysis of cell responses, biotransformation pathways in cells and recombinant approaches to the early detection of cell stress are also covered in detail. Prominent features of in vitro technologies also include regulation, biosafety, and standardisation. Dedicated chapters deal with these issues in a practical way in order to lead the reader to the right source of information. This book provides an up-to-date, informative and practical review of cell culture methods for in vitro toxicology.