Soon after the conclusion of Vampire War: Fallout, the vampires are continuing their plan of conquest from their solidified base in a suburb of New Orleans while the surviving humans, now sequestered in the walled town of Sanctuary, which has also become the home of President Penny Kramer making it the new national capitol, continue to plan for their survival. The President and the former DSA task forcfe are at odds over the direction of their fight. With a little subterfuge and outside influence, as well as some drastic changes, the course is chosen for them.