This handbook will help veterinary clinicians and their staff to manage cases of poisoning in dogs and cats. It will also help answer enquiries about potential poisonings received from concerned pet owners. The content has been compiled from over 15 000 past cases referred to the Veterinary Poisons Information Service – a 24–hour information service for veterinary surgeons. The VPIS experience is compared and contrasted with case data and reports from the literature to provide a comprehensive overview of both toxicity and management for the agents included. Each agent, or group of agents, has a separate chapter covering its effects in either the cat or the dog. In some cases the species information is combined where the clinical effects and management are identical. The chapters provide all the information necessary for the immediate management of a particular poisoning case. This includes doses at which clinical intervention is advisable and dosing regimens and indications for any drug therapy required. Thus the user will be able to access quickly all the information needed for an emergency situation without having to refer to other sources.